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“Balance is critical,” cautions Bowe. “Retinol can be very irritating if used too frequently or if the formulation is too strong for your skin.” She recommends starting off with a pea-sized amount of a low percentage over-the-counter formula (.01% to 0.03%), and using it “two times per week, slowly increasing the usage to give the skin a chance to acclimate.” Moreover, you should skip your retinol product on the day before you exfoliate (Bowe recommends exfoliating two to three times per week). “Exfoliating is abrasive and irritating, and you do not want to compound the skin irritation by heightening your skin’s sensitivity,” she says, adding that if you’re getting certain in-office treatments like lasers, microneedling, microdermabrasion, you will want to take a break from your retinol. In the spirit of not overdoing it, there’s a spate of new time-release formulas fit for skin types prone to redness or breakouts. “They’re a good option for people who have sensitive skin,” explains Fusco. “It releases the active ingredient over time and may offer less irritation.” In terms of prescription retinol versus something over the counter, the former is much more potent with a higher percentage of retinol, and one may graduate to it over time, says Bowe.

Here, experts break down how to carefully incorporate the powerhouse ingredient into your regimen to achieve a supernaturally fresh-faced complexion, now and for decades to come. Thirty has long been the banner year for introducing retinol into one’s routine, but many women are starting before then, motivated by early signs of aging, such as sun spots or crows feet, or simply eager to get a head start and utilize the latest technologies under the careful watch of their dermatologist. “Your mid-twenties are a great time to start using retinol,” says Ellen Marmur, M.D. “Many patients who have used it for years swear by it.”

While certain side effects, such as mild irritation, dryness, and sun sensitivity, are normal as your skin adjusts to the active ingredient, intense flaking, redness, and burning are not and those with especially sensitive skin, or who struggle with conditions like rosacea or eczema, should be wary of retinol or shy away from it altogether. “If you cannot tolerate retinol, don’t worry,” says Marmur. “It’s not the only anti-ager! There are plenty of amazing anti-aging ingredients, such as wild indigo, that work beautifully without any irritation or sun sensitivity.”

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